Modeling cortical spreading depression induced by the hyperactivity of interneurons
نویسندگان
چکیده
منابع مشابه
Modeling the spreading cortical depression wavefront.
Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2-5 mm/min and is followed by a 5-10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain surfaces. The usefulness of the technique is demonstrate...
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The nonlinear wave phenomenon of cortical spreading depression (SD), which occurs in many brain structures, has mathematical similarities to neuronal spiking but on very different space and time scales. Its properties and previous modeling are briefly reviewed. A model consisting of a 6-component reaction-diffusion system in two space dimensions is described. With 3-parameter Poisson process so...
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Ketamine (KET) induced blockade of cortical spreading depression (CSD) declines with repeated KET applications in a way suggesting the development of tolerance. Possible mechanism of this process was studied in 31 rats anestheized with pentobarbital. CSD was elicited by injection of 1µl of 5% KCl into cortex at 15 min intervals and monitored by recording the accompanying slow potential waves....
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ژورنال
عنوان ژورنال: Journal of Computational Neuroscience
سال: 2019
ISSN: 0929-5313,1573-6873
DOI: 10.1007/s10827-019-00730-8